Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells

Innate immune factors may restrict hematopoietic stem cell (HSC) genetic engineering and contribute to broad individual variability in gene therapy outcomes. Here, we show that HSCs harbor an early, constitutively active innate immune block to lentiviral transduction that can be efficiently overcome...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Petrillo, Carolina, Thorne, Lucy G., Unali, Giulia, Schiroli, Giulia, Giordano, Anna M.S., Piras, Francesco, Cuccovillo, Ivan, Petit, Sarah J., Ahsan, Fatima, Noursadeghi, Mahdad, Clare, Simon, Genovese, Pietro, Gentner, Bernhard, Naldini, Luigi, Towers, Greg J., Kajaste-Rudnitski, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6292841/
https://ncbi.nlm.nih.gov/pubmed/30416070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.10.008
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