SIRT2 knockout exacerbates insulin resistance in high fat-fed mice

The NAD(+)-dependent deacetylase SIRT2 is unique amongst sirtuins as it is effective in the cytosol, as well as the mitochondria. Defining the role of cytosolic acetylation state in specific tissues is difficult since even physiological effects at the whole body level are unknown. We hypothesized th...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lantier, Louise, Williams, Ashley S., Hughey, Curtis C., Bracy, Deanna P., James, Freyja D., Ansari, Muhammad A., Gius, David, Wasserman, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289500/
https://ncbi.nlm.nih.gov/pubmed/30533032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0208634
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