Relaxin Treatment Reverses Insulin Resistance in Mice Fed a High-Fat Diet

The endogenous hormone relaxin increases vascular reactivity and angiogenesis. We demonstrate that acute relaxin infusion in lean C57BL/6J mice enhances skeletal muscle perfusion and augments muscle glucose uptake during a hyperinsulinemic-euglycemic clamp. However, an acute effect was absent in mic...

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Bibliographic Details
Main Authors: Bonner, Jeffrey S., Lantier, Louise, Hocking, Kyle M., Kang, Li, Owolabi, Mark, James, Freyja D., Bracy, Deanna P., Brophy, Colleen M., Wasserman, David H.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2013
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749347/
https://ncbi.nlm.nih.gov/pubmed/23801576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0033
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