SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat–Fed Mice

Protein hyperacetylation is associated with glucose intolerance and insulin resistance, suggesting that the enzymes regulating the acetylome play a role in this pathological process. Sirtuin 3 (SIRT3), the primary mitochondrial deacetylase, has been linked to energy homeostasis. Thus, it is hypothes...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Lantier, Louise, Williams, Ashley S., Williams, Ian M., Yang, Karen K., Bracy, Deanna P., Goelzer, Mickael, James, Freyja D., Gius, David, Wasserman, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2015
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542443/
https://ncbi.nlm.nih.gov/pubmed/25948682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-1810
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