SIRT2 knockout exacerbates insulin resistance in high fat-fed mice

The NAD(+)-dependent deacetylase SIRT2 is unique amongst sirtuins as it is effective in the cytosol, as well as the mitochondria. Defining the role of cytosolic acetylation state in specific tissues is difficult since even physiological effects at the whole body level are unknown. We hypothesized th...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Lantier, Louise, Williams, Ashley S., Hughey, Curtis C., Bracy, Deanna P., James, Freyja D., Ansari, Muhammad A., Gius, David, Wasserman, David H.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289500/
https://ncbi.nlm.nih.gov/pubmed/30533032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0208634
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