SIRT2 knockout exacerbates insulin resistance in high fat-fed mice

The NAD(+)-dependent deacetylase SIRT2 is unique amongst sirtuins as it is effective in the cytosol, as well as the mitochondria. Defining the role of cytosolic acetylation state in specific tissues is difficult since even physiological effects at the whole body level are unknown. We hypothesized th...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Lantier, Louise, Williams, Ashley S., Hughey, Curtis C., Bracy, Deanna P., James, Freyja D., Ansari, Muhammad A., Gius, David, Wasserman, David H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2018
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289500/
https://ncbi.nlm.nih.gov/pubmed/30533032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0208634
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