SIRT2 knockout exacerbates insulin resistance in high fat-fed mice

The NAD(+)-dependent deacetylase SIRT2 is unique amongst sirtuins as it is effective in the cytosol, as well as the mitochondria. Defining the role of cytosolic acetylation state in specific tissues is difficult since even physiological effects at the whole body level are unknown. We hypothesized th...

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Publicat a:PLoS One
Autors principals: Lantier, Louise, Williams, Ashley S., Hughey, Curtis C., Bracy, Deanna P., James, Freyja D., Ansari, Muhammad A., Gius, David, Wasserman, David H.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289500/
https://ncbi.nlm.nih.gov/pubmed/30533032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0208634
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