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Glucagon-Like Peptide-1 Receptor Knockout Mice Are Protected from High-Fat Diet-Induced Insulin Resistance

Glucagon-like peptide-1 augments nutrient-stimulated insulin secretion. Chow-fed mice lacking the glucagon-like peptide-1 receptor (Glp1r) exhibit enhanced insulin-stimulated muscle glucose uptake but impaired suppression of endogenous glucose appearance (endoR(a)). This proposes a novel role for th...

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Detalhes bibliográficos
Main Authors: Ayala, Julio E., Bracy, Deanna P., James, Freyja D., Burmeister, Melissa A., Wasserman, David H., Drucker, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2946144/
https://ncbi.nlm.nih.gov/pubmed/20685876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0289
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