B cell-specific diversion of glucose carbon utilization reveals a unique vulnerability in B cell malignancies

B-cell activation during normal immune responses and oncogenic transformation impose increased metabolic demands on B-cells and their ability to retain redox homeostasis. While the serine/threonine-protein phosphatase 2A (PP2A) was identified as tumor suppressor in multiple types of cancer, our gene...

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Udgivet i:Cell
Main Authors: Xiao, Gang, Chan, Lai N., Klemm, Lars, Braas, Daniel, Chen, Zhengshan, Geng, Huimin, Zhang, Qiuyi Chen, Aghajanirefah, Ali, Cosgun, Kadriye Nehir, Sadras, Teresa, Lee, Jaewoong, Mirzapoiazova, Tamara, Salgia, Ravi, Ernst, Thomas, Hochhaus, Andreas, Jumaa, Hassan, Jiang, Xiaoyan, Weinstock, David M., Graeber, Thomas G., Müschen, Markus
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284818/
https://ncbi.nlm.nih.gov/pubmed/29551267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.02.048
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