PTEN opposes negative selection and enables oncogenic transformation of pre-B cells

PTEN is a negative regulator of PI3K-AKT signaling and a potent tumor suppressor in many types of cancer. To test a tumor suppressive role of PTEN in pre-B acute lymphoblastic leukemia (ALL), we induced Cre-mediated deletion of Pten in mouse models of pre-B ALL. In contrast to its role as a tumor su...

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Publicado no:Nat Med
Main Authors: Shojaee, Seyedmehdi, Chan, Lai N., Buchner, Maike, Cazzaniga, Valeria, Cosgun, Kadriye Nehir, Geng, Huimin, Qiu, Yi Hua, von Minden, Marcus Dühren, Ernst, Thomas, Hochhaus, Andreas, Cazzaniga, Giovanni, Melnick, Ari, Kornblau, Steven M., Graeber, Thomas G., Wu, Hong, Jumaa, Hassan, Müschen, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5178869/
https://ncbi.nlm.nih.gov/pubmed/26974310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4062
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