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B cell-specific diversion of glucose carbon utilization reveals a unique vulnerability in B cell malignancies

B-cell activation during normal immune responses and oncogenic transformation impose increased metabolic demands on B-cells and their ability to retain redox homeostasis. While the serine/threonine-protein phosphatase 2A (PP2A) was identified as tumor suppressor in multiple types of cancer, our gene...

詳細記述

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書誌詳細
出版年:Cell
主要な著者: Xiao, Gang, Chan, Lai N., Klemm, Lars, Braas, Daniel, Chen, Zhengshan, Geng, Huimin, Zhang, Qiuyi Chen, Aghajanirefah, Ali, Cosgun, Kadriye Nehir, Sadras, Teresa, Lee, Jaewoong, Mirzapoiazova, Tamara, Salgia, Ravi, Ernst, Thomas, Hochhaus, Andreas, Jumaa, Hassan, Jiang, Xiaoyan, Weinstock, David M., Graeber, Thomas G., Müschen, Markus
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6284818/
https://ncbi.nlm.nih.gov/pubmed/29551267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.02.048
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