Metabolic gatekeeper function of B-lymphoid transcription factors

B-lymphoid transcription factors (e.g. PAX5, IKZF1) are critical for early B-cell development(1–2), yet genetic lesions occur in >80% of cases of B-cell acute lymphoblastic leukemia (ALL)(3–4). The significance of these lesions in ALL remained unclear. Combining ChIP-seq and RNA-seq studies, we i...

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Publicado no:Nature
Main Authors: Chan, Lai N., Chen, Zhengshan, Braas, Daniel, Lee, Jae-Woong, Xiao, Gang, Geng, Huimin, Cosgun, Kadriye Nehir, Hurtz, Christian, Shojaee, Seyedmehdi, Cazzaniga, Valeria, Schjerven, Hilde, Ernst, Thomas, Hochhaus, Andreas, Kornblau, Steven M., Konopleva, Marina, Pufall, Miles A., Cazzaniga, Giovanni, Liu, Grace J., Milne, Thomas A., Koeffler, H. Philip, Ross, Theodora S., Sanchez-Garcia, Isidro, Borkhardt, Arndt, Yamamoto, Keith R., Dickins, Ross A., Graeber, Thomas G., Müschen, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621518/
https://ncbi.nlm.nih.gov/pubmed/28192788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21076
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