Metabolic gatekeeper function of B-lymphoid transcription factors

B-lymphoid transcription factors (e.g. PAX5, IKZF1) are critical for early B-cell development(1–2), yet genetic lesions occur in >80% of cases of B-cell acute lymphoblastic leukemia (ALL)(3–4). The significance of these lesions in ALL remained unclear. Combining ChIP-seq and RNA-seq studies, we i...

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出版年:Nature
主要な著者: Chan, Lai N., Chen, Zhengshan, Braas, Daniel, Lee, Jae-Woong, Xiao, Gang, Geng, Huimin, Cosgun, Kadriye Nehir, Hurtz, Christian, Shojaee, Seyedmehdi, Cazzaniga, Valeria, Schjerven, Hilde, Ernst, Thomas, Hochhaus, Andreas, Kornblau, Steven M., Konopleva, Marina, Pufall, Miles A., Cazzaniga, Giovanni, Liu, Grace J., Milne, Thomas A., Koeffler, H. Philip, Ross, Theodora S., Sanchez-Garcia, Isidro, Borkhardt, Arndt, Yamamoto, Keith R., Dickins, Ross A., Graeber, Thomas G., Müschen, Markus
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621518/
https://ncbi.nlm.nih.gov/pubmed/28192788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21076
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