PON2 subverts metabolic gatekeeper functions in B cells to promote leukemogenesis

Unlike other cell types, developing B cells undergo multiple rounds of somatic recombination and hypermutation to evolve high-affinity antibodies. Reflecting the high frequency of DNA double-strand breaks, adaptive immune protection by B cells comes with an increased risk of malignant transformation...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Pan, Lili, Hong, Chao, Chan, Lai N., Xiao, Gang, Malvi, Parmanand, Robinson, Mark E., Geng, Huimin, Reddy, Srinivasa T., Lee, Jaewoong, Khairnar, Vishal, Cosgun, Kadriye Nehir, Xu, Liang, Kume, Kohei, Sadras, Teresa, Wang, Shaoyuan, Wajapeyee, Narendra, Müschen, Markus
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2021
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7896313/
https://ncbi.nlm.nih.gov/pubmed/33531346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2016553118
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