Loading...
PON2 subverts metabolic gatekeeper functions in B cells to promote leukemogenesis
Unlike other cell types, developing B cells undergo multiple rounds of somatic recombination and hypermutation to evolve high-affinity antibodies. Reflecting the high frequency of DNA double-strand breaks, adaptive immune protection by B cells comes with an increased risk of malignant transformation...
Saved in:
| Published in: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2021
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7896313/ https://ncbi.nlm.nih.gov/pubmed/33531346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2016553118 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|