IFITM3 functions as PIP3-scaffold to amplify PI3K signaling in B-cells

Ifitm3 was previously identified as an endosomal protein that blocks viral infection(1–3). Studying clinical cohorts of B-cell leukemia and lymphoma patients, we identified IFITM3 as a strong predictor of poor outcome. In normal resting B-cells, Ifitm3 was minimally expressed and mainly localized in...

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Publicat a:Nature
Autors principals: Lee, Jaewoong, Robinson, Mark E., Ma, Ning, Artadji, Dewan, Ahmed, Mohamed A., Xiao, Gang, Sadras, Teresa, Deb, Gauri, Winchester, Janet, Cosgun, Kadriye Nehir, Geng, Huimin, Chan, Lai N., Kume, Kohei, Miettinen, Teemu P., Zhang, Ye, Nix, Matthew A., Klemm, Lars, Chen, Chun Wei, Chen, Jianjun, Khairnar, Vishal, Wiita, Arun P., Thomas-Tikhonenko, Andrei, Farzan, Michael, Jung, Jae U., Weinstock, David M., Manalis, Scott R., Diamond, Michael S., Vaidehi, Nagarajan, Müschen, Markus
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087162/
https://ncbi.nlm.nih.gov/pubmed/33149299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2884-6
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