PTEN opposes negative selection and enables oncogenic transformation of pre-B cells

PTEN is a negative regulator of PI3K-AKT signaling and a potent tumor suppressor in many types of cancer. To test a tumor suppressive role of PTEN in pre-B acute lymphoblastic leukemia (ALL), we induced Cre-mediated deletion of Pten in mouse models of pre-B ALL. In contrast to its role as a tumor su...

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Vydáno v:Nat Med
Hlavní autoři: Shojaee, Seyedmehdi, Chan, Lai N., Buchner, Maike, Cazzaniga, Valeria, Cosgun, Kadriye Nehir, Geng, Huimin, Qiu, Yi Hua, von Minden, Marcus Dühren, Ernst, Thomas, Hochhaus, Andreas, Cazzaniga, Giovanni, Melnick, Ari, Kornblau, Steven M., Graeber, Thomas G., Wu, Hong, Jumaa, Hassan, Müschen, Markus
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5178869/
https://ncbi.nlm.nih.gov/pubmed/26974310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4062
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