Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia

B cells are selected for an intermediate level of B cell receptor (BCR) signaling strength: Attenuation below minimum (e.g. non-functional BCR)(1) or hyperactivation above maximum (e.g. self-reactive BCR)(2–3) thresholds of signaling strength causes negative selection. In ~25% of cases, acute lympho...

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Publicado no:Nature
Main Authors: Chen, Zhengshan, Shojaee, Seyedmehdi, Buchner, Maike, Geng, Huimin, Lee, Jae Woong, Klemm, Lars, Titz, Björn, Graeber, Thomas G., Park, Eugene, Tan, Ying Xim, Satterthwaite, Anne, Paietta, Elisabeth, Hunger, Stephen P., Willman, Cheryl L., Melnick, Ari, Loh, Mignon L., Jung, Jae U., Coligan, John E., Bolland, Silvia, Mak, Tak W., Limnander, Andre, Jumaa, Hassan, Reth, Michael, Weiss, Arthur, Lowell, Clifford A., Müschen, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441554/
https://ncbi.nlm.nih.gov/pubmed/25799995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14231
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