Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia

B cells are selected for an intermediate level of B cell receptor (BCR) signaling strength: Attenuation below minimum (e.g. non-functional BCR)(1) or hyperactivation above maximum (e.g. self-reactive BCR)(2–3) thresholds of signaling strength causes negative selection. In ~25% of cases, acute lympho...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nature
Main Authors: Chen, Zhengshan, Shojaee, Seyedmehdi, Buchner, Maike, Geng, Huimin, Lee, Jae Woong, Klemm, Lars, Titz, Björn, Graeber, Thomas G., Park, Eugene, Tan, Ying Xim, Satterthwaite, Anne, Paietta, Elisabeth, Hunger, Stephen P., Willman, Cheryl L., Melnick, Ari, Loh, Mignon L., Jung, Jae U., Coligan, John E., Bolland, Silvia, Mak, Tak W., Limnander, Andre, Jumaa, Hassan, Reth, Michael, Weiss, Arthur, Lowell, Clifford A., Müschen, Markus
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441554/
https://ncbi.nlm.nih.gov/pubmed/25799995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14231
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker