Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia

B cells are selected for an intermediate level of B cell receptor (BCR) signaling strength: Attenuation below minimum (e.g. non-functional BCR)(1) or hyperactivation above maximum (e.g. self-reactive BCR)(2–3) thresholds of signaling strength causes negative selection. In ~25% of cases, acute lympho...

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書誌詳細
出版年:Nature
主要な著者: Chen, Zhengshan, Shojaee, Seyedmehdi, Buchner, Maike, Geng, Huimin, Lee, Jae Woong, Klemm, Lars, Titz, Björn, Graeber, Thomas G., Park, Eugene, Tan, Ying Xim, Satterthwaite, Anne, Paietta, Elisabeth, Hunger, Stephen P., Willman, Cheryl L., Melnick, Ari, Loh, Mignon L., Jung, Jae U., Coligan, John E., Bolland, Silvia, Mak, Tak W., Limnander, Andre, Jumaa, Hassan, Reth, Michael, Weiss, Arthur, Lowell, Clifford A., Müschen, Markus
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441554/
https://ncbi.nlm.nih.gov/pubmed/25799995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14231
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