Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia

B cells are selected for an intermediate level of B cell receptor (BCR) signaling strength: Attenuation below minimum (e.g. non-functional BCR)(1) or hyperactivation above maximum (e.g. self-reactive BCR)(2–3) thresholds of signaling strength causes negative selection. In ~25% of cases, acute lympho...

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Published in:Nature
Main Authors: Chen, Zhengshan, Shojaee, Seyedmehdi, Buchner, Maike, Geng, Huimin, Lee, Jae Woong, Klemm, Lars, Titz, Björn, Graeber, Thomas G., Park, Eugene, Tan, Ying Xim, Satterthwaite, Anne, Paietta, Elisabeth, Hunger, Stephen P., Willman, Cheryl L., Melnick, Ari, Loh, Mignon L., Jung, Jae U., Coligan, John E., Bolland, Silvia, Mak, Tak W., Limnander, Andre, Jumaa, Hassan, Reth, Michael, Weiss, Arthur, Lowell, Clifford A., Müschen, Markus
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441554/
https://ncbi.nlm.nih.gov/pubmed/25799995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14231
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