Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia

Despite recent advances in the cure rate of acute lymphoblastic leukaemia (ALL), the prognosis for patients with relapsed ALL remains poor. Here we identify FOXM1 as a candidate responsible for an aggressive clinical course. We show that FOXM1 levels peak at the pre-B-cell receptor checkpoint but ar...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Buchner, Maike, Park, Eugene, Geng, Huimin, Klemm, Lars, Flach, Johanna, Passegué, Emmanuelle, Schjerven, Hilde, Melnick, Ari, Paietta, Elisabeth, Kopanja, Dragana, Raychaudhuri, Pradip, Müschen, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366523/
https://ncbi.nlm.nih.gov/pubmed/25753524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7471
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