Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia

Despite recent advances in the cure rate of acute lymphoblastic leukaemia (ALL), the prognosis for patients with relapsed ALL remains poor. Here we identify FOXM1 as a candidate responsible for an aggressive clinical course. We show that FOXM1 levels peak at the pre-B-cell receptor checkpoint but ar...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Buchner, Maike, Park, Eugene, Geng, Huimin, Klemm, Lars, Flach, Johanna, Passegué, Emmanuelle, Schjerven, Hilde, Melnick, Ari, Paietta, Elisabeth, Kopanja, Dragana, Raychaudhuri, Pradip, Müschen, Markus
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4366523/
https://ncbi.nlm.nih.gov/pubmed/25753524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7471
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