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SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia
The Sox4 transcription factor mediates early B-cell differentiation. Compared with normal pre-B cells, SOX4 promoter regions in Ph(+) ALL cells are significantly hypomethylated. Loss and gain-of-function experiments identified Sox4 as a critical activator of PI3K/AKT and MAPK signaling in ALL cells....
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3538327/ https://ncbi.nlm.nih.gov/pubmed/23152540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-05-428938 |
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