SOX4 enables oncogenic survival signals in acute lymphoblastic leukemia

The Sox4 transcription factor mediates early B-cell differentiation. Compared with normal pre-B cells, SOX4 promoter regions in Ph(+) ALL cells are significantly hypomethylated. Loss and gain-of-function experiments identified Sox4 as a critical activator of PI3K/AKT and MAPK signaling in ALL cells....

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Bibliographic Details
Main Authors: Ramezani-Rad, Parham, Geng, Huimin, Hurtz, Christian, Chan, Lai N., Chen, Zhengshan, Jumaa, Hassan, Melnick, Ari, Paietta, Elisabeth, Carroll, William L., Willman, Cheryl L., Lefebvre, Véronique, Müschen, Markus
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2013
Subjects:
Lymphoid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538327/
https://ncbi.nlm.nih.gov/pubmed/23152540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-05-428938
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