Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia

The unfolded protein response (UPR) pathway, a stress-induced signaling cascade emanating from the endoplasmic reticulum (ER), regulates the expression and activity of molecules including BiP (HSPA5), IRE1 (ERN1), Blimp-1 (PRDM1), and X-box binding protein 1 (XBP1). These molecules are required for...

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Detalhes bibliográficos
Main Authors: Kharabi Masouleh, Behzad, Geng, Huimin, Hurtz, Christian, Chan, Lai N., Logan, Aaron C., Chang, Mi Sook, Huang, Chuanxin, Swaminathan, Srividya, Sun, Haibo, Paietta, Elisabeth, Melnick, Ari M., Koeffler, Phillip, Müschen, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040579/
https://ncbi.nlm.nih.gov/pubmed/24821775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400958111
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