Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia

The unfolded protein response (UPR) pathway, a stress-induced signaling cascade emanating from the endoplasmic reticulum (ER), regulates the expression and activity of molecules including BiP (HSPA5), IRE1 (ERN1), Blimp-1 (PRDM1), and X-box binding protein 1 (XBP1). These molecules are required for...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kharabi Masouleh, Behzad, Geng, Huimin, Hurtz, Christian, Chan, Lai N., Logan, Aaron C., Chang, Mi Sook, Huang, Chuanxin, Swaminathan, Srividya, Sun, Haibo, Paietta, Elisabeth, Melnick, Ari M., Koeffler, Phillip, Müschen, Markus
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2014
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040579/
https://ncbi.nlm.nih.gov/pubmed/24821775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400958111
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