Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia

The unfolded protein response (UPR) pathway, a stress-induced signaling cascade emanating from the endoplasmic reticulum (ER), regulates the expression and activity of molecules including BiP (HSPA5), IRE1 (ERN1), Blimp-1 (PRDM1), and X-box binding protein 1 (XBP1). These molecules are required for...

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Dades bibliogràfiques
Autors principals: Kharabi Masouleh, Behzad, Geng, Huimin, Hurtz, Christian, Chan, Lai N., Logan, Aaron C., Chang, Mi Sook, Huang, Chuanxin, Swaminathan, Srividya, Sun, Haibo, Paietta, Elisabeth, Melnick, Ari M., Koeffler, Phillip, Müschen, Markus
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040579/
https://ncbi.nlm.nih.gov/pubmed/24821775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400958111
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