Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia

Chromosomal rearrangements of the mixed lineage leukemia (MLL) gene occur in ∼10% of B-cell acute lymphoblastic leukemia (B-ALL) and define a group of patients with dismal outcomes. Immunohistochemical staining of bone marrow biopsies from most of these patients revealed aberrant expression of BCL6,...

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Detalles Bibliográficos
Publicado en:Genes Dev
Main Authors: Hurtz, Christian, Chan, Lai N., Geng, Huimin, Ballabio, Erica, Xiao, Gang, Deb, Gauri, Khoury, Haytham, Chen, Chun-Wei, Armstrong, Scott A., Chen, Jianjun, Ernst, Patricia, Melnick, Ari, Milne, Thomas, Müschen, Markus
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2019
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6719625/
https://ncbi.nlm.nih.gov/pubmed/31395741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.327593.119
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