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Drugging the unfolded protein response in acute leukemias
The unfolded protein response (UPR), an endoplasmic reticulum (ER) stress-induced signaling cascade, is mediated by three major stress sensors IRE-1α, PERK, and ATF6α. Studies described the UPR as a critical network in selection, adaptation, and survival of cancer cells. While previous reviews focus...
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| Publicado no: | J Hematol Oncol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4504168/ https://ncbi.nlm.nih.gov/pubmed/26179601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-015-0184-7 |
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