Infliction of proteotoxic stresses by impairment of the unfolded protein response or proteasomal inhibition as a therapeutic strategy for mast cell leukemia

The intensity and duration of endoplasmic reticulum (ER) stress converts the unfolded protein response (UPR) from an adaptive into a terminal response. The first regulates homeostasis, the latter triggers apoptosis. Cells that rapidly proliferate and possess developed secretory capabilities, such as...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wilhelm, Thomas, Bick, Fabian, Peters, Kerstin, Mohta, Vrinda, Tirosh, Boaz, Patterson, John B., Kharabi-Masouleh, Behzad, Huber, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790440/
https://ncbi.nlm.nih.gov/pubmed/29423023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.23354
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