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Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy
Genomic alterations may make cancer cells more dependent than normal cells on mechanisms of proteostasis, including protein folding and degradation. This proposition is the basis for the clinical use of proteasome inhibitors to treat multiple myeloma and mantle cell lymphoma. However, proteasome inh...
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| Publicado no: | BMC Biol |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4226866/ https://ncbi.nlm.nih.gov/pubmed/25385277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-014-0094-0 |
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