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Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody
The N-glycans attached to the Fab and Fc domains play distinct roles in modulating the functions of antibodies. However, posttranslational site-selective modifications of glycans in antibodies and other multiply glycosylated proteins remain a challenging task. Here, we report a chemoenzymatic method...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6255169/ https://ncbi.nlm.nih.gov/pubmed/30397147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1812833115 |
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