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Chemoenzymatic Glycoengineering of Intact IgG Antibodies for Gain of Functions

The fine structures of Fc N-glycans can modulate the effector functions of IgG antibodies. It has been demonstrated that lack of the core fucose on the Fc N-glycans leads to drastic enhancement of antibody-dependent cellular cytotoxicity (ADCC), while terminal α2,6-sialylation of Fc glycan plays a c...

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Detalhes bibliográficos
Main Authors: Huang, Wei, Giddens, John, Fan, Shu-Quan, Toonstra, Christian, Wang, Lai-Xi
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3427744/
https://ncbi.nlm.nih.gov/pubmed/22747414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3051266
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