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Chemoenzymatic synthesis of glycoengineered IgG antibodies and glycosite-specific antibody–drug conjugates

Glycoengineered therapeutic antibodies and glycosite-specific antibody–drug conjugates (gsADCs) have generated great interest among researchers because of their therapeutic potential. Endoglycosidase-catalyzed in vitro glycoengineering technology is a powerful tool for IgG Fc (fragment cystallizable...

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Publicat a:Nat Protoc
Autors principals: Tang, Feng, Wang, Lai-Xi, Huang, Wei
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705183/
https://ncbi.nlm.nih.gov/pubmed/28749929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2017.058
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