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Chemoenzymatic Glycoengineering of Intact IgG Antibodies for Gain of Functions
The fine structures of Fc N-glycans can modulate the effector functions of IgG antibodies. It has been demonstrated that lack of the core fucose on the Fc N-glycans leads to drastic enhancement of antibody-dependent cellular cytotoxicity (ADCC), while terminal α2,6-sialylation of Fc glycan plays a c...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3427744/ https://ncbi.nlm.nih.gov/pubmed/22747414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3051266 |
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