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Modulating IgG effector function by Fc glycan engineering

IgG antibodies contain a conserved N-glycosylation site on the Fc domain to which a complex, biantennary glycan is attached. The fine structures of this glycan modulate antibody effector functions by affecting the binding affinity of the Fc to diverse Fc receptor family members. For example, core fu...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Li, Tiezheng, DiLillo, David J., Bournazos, Stylianos, Giddens, John P., Ravetch, Jeffrey V., Wang, Lai-Xi
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380036/
https://ncbi.nlm.nih.gov/pubmed/28289219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702173114
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