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Modulating IgG effector function by Fc glycan engineering

IgG antibodies contain a conserved N-glycosylation site on the Fc domain to which a complex, biantennary glycan is attached. The fine structures of this glycan modulate antibody effector functions by affecting the binding affinity of the Fc to diverse Fc receptor family members. For example, core fu...

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Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Li, Tiezheng, DiLillo, David J., Bournazos, Stylianos, Giddens, John P., Ravetch, Jeffrey V., Wang, Lai-Xi
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380036/
https://ncbi.nlm.nih.gov/pubmed/28289219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702173114
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