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Site-specific immobilization of endoglycosidases for streamlined chemoenzymatic glycan remodeling of antibodies

Chemoenzymatic glycan remodeling of antibodies using an endoglycosidase and its mutant is emerging as an attractive approach for producing homogeneous antibody glycoforms. We report in this paper a site-specific covalent immobilization of the endoglycosidases (Endo-S2 and its glycosynthase mutant D1...

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Vydáno v:Carbohydr Res
Hlavní autoři: Li, Tiezheng, Li, Chao, Quan, David N., Bentley, William E., Wang, Lai-Xi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837956/
https://ncbi.nlm.nih.gov/pubmed/29475193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.carres.2018.02.007
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