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One-Pot Enzymatic Glycan Remodeling of a Therapeutic Monoclonal Antibody by Endoglycosidase S (Endo-S) From Streptococcus pyogenes
A facile, one-pot enzymatic glycan remodeling of antibody rituximab to produce homogeneous high-mannose and hybrid type antibody glycoforms is described. This method was based on the unique substrate specificity of the endoglycosidase S (Endo-S) from Streptococcus pyogenes. While Endo-S efficiently...
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| Veröffentlicht in: | Bioorg Med Chem |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5788734/ https://ncbi.nlm.nih.gov/pubmed/28789910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.07.053 |
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