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Generation and Comparative Kinetic Analysis of New Glycosynthase Mutants from Streptococcus pyogenes Endoglycosidases for Antibody Glycoengineering

Chemoenzymatic glycan remodeling by endoglycosidase-catalyzed deglycosylation and reglycosylation is emerging as an attractive approach for producing homogeneous glycoforms of antibodies, and the success of this approach depends on the discovery of efficient endoglycosidases and their glycosynthase...

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Bibliographische Detailangaben
Veröffentlicht in:Biochemistry
Hauptverfasser: Tong, Xin, Li, Tiezheng, Li, Chao, Wang, Lai-Xi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202118/
https://ncbi.nlm.nih.gov/pubmed/30102520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00719
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