Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies

To evade host immune mechanisms, many bacteria secrete immunomodulatory enzymes. Streptococcus pyogenes, one of the most common human pathogens, secretes a large endoglycosidase, EndoS, which removes carbohydrates in a highly specific manner from IgG antibodies. This modification renders antibodies...

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Autors principals: Trastoy, Beatriz, Lomino, Joseph V., Pierce, Brian G., Carter, Lester G., Günther, Sebastian, Giddens, John P., Snyder, Greg A., Weiss, Thomas M., Weng, Zhiping, Wang, Lai-Xi, Sundberg, Eric J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020096/
https://ncbi.nlm.nih.gov/pubmed/24753590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322908111
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