Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies

To evade host immune mechanisms, many bacteria secrete immunomodulatory enzymes. Streptococcus pyogenes, one of the most common human pathogens, secretes a large endoglycosidase, EndoS, which removes carbohydrates in a highly specific manner from IgG antibodies. This modification renders antibodies...

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Bibliografske podrobnosti
Main Authors: Trastoy, Beatriz, Lomino, Joseph V., Pierce, Brian G., Carter, Lester G., Günther, Sebastian, Giddens, John P., Snyder, Greg A., Weiss, Thomas M., Weng, Zhiping, Wang, Lai-Xi, Sundberg, Eric J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020096/
https://ncbi.nlm.nih.gov/pubmed/24753590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322908111
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