Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies

To evade host immune mechanisms, many bacteria secrete immunomodulatory enzymes. Streptococcus pyogenes, one of the most common human pathogens, secretes a large endoglycosidase, EndoS, which removes carbohydrates in a highly specific manner from IgG antibodies. This modification renders antibodies...

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Detalles Bibliográficos
Main Authors: Trastoy, Beatriz, Lomino, Joseph V., Pierce, Brian G., Carter, Lester G., Günther, Sebastian, Giddens, John P., Snyder, Greg A., Weiss, Thomas M., Weng, Zhiping, Wang, Lai-Xi, Sundberg, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020096/
https://ncbi.nlm.nih.gov/pubmed/24753590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322908111
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