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Structure-based discovery and development of cyclin-dependent protein kinase inhibitors

The cell fate-determining roles played by members of the cyclin-dependent protein kinase (CDK) family explain why their dysregulation can promote proliferative diseases, and identify them as potential targets for drug discovery in oncology and beyond. After many years of research, the first efficaci...

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Detalhes bibliográficos
Publicado no:Essays Biochem
Main Authors: Martin, Mathew P, Endicott, Jane A., Noble, Martin E.M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6248306/
https://ncbi.nlm.nih.gov/pubmed/29118092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/EBC20170040
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