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Inhibitors of Cyclin-Dependent Kinases as Cancer Therapeutics

Over the past two decades there has been a great deal of interest in the development of inhibitors of the Cyclin-dependent kinases (CDKs). This attention initially stemmed from observations that different CDK isoforms have key roles in cancer cell proliferation through loss of regulation of the cell...

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Bibliographic Details
Published in:Pharmacol Ther
Main Authors: Whittaker, Steven R., Mallinger, Aurelie, Workman, Paul, Clarke, Paul A.
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6141011/
https://ncbi.nlm.nih.gov/pubmed/28174091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2017.02.008
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