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Structure-based discovery of the first allosteric inhibitors of cyclin-dependent kinase 2
Allosteric targeting of protein kinases via displacement of the structural αC helix with type III allosteric inhibitors is currently gaining a foothold in drug discovery. Recently, the first crystal structure of CDK2 with an open allosteric pocket adjacent to the αC helix has been described, prospec...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4111683/ https://ncbi.nlm.nih.gov/pubmed/24911186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.29295 |
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