A single residue switch reveals principles of antibody domain integrity

Despite their importance for antibody architecture and design, the principles governing antibody domain stability are still not understood in sufficient detail. Here, to address this question, we chose a domain from the invariant part of IgG, the C(H)2 domain. We found that compared with other Ig do...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Weber, Benedikt, Brandl, Matthias J., Pulido Cendales, María Daniela, Berner, Carolin, Pradhan, Tejaswini, Feind, Gina Maria, Zacharias, Martin, Reif, Bernd, Buchner, Johannes
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2018
Sujets:
Protein Structure and Folding
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222096/
https://ncbi.nlm.nih.gov/pubmed/30228183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005475
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