Seeded fibrils of the germline variant of human λ-III immunoglobulin light chain FOR005 have a similar core as patient fibrils with reduced stability

Systemic antibody light chains (AL) amyloidosis is characterized by deposition of amyloid fibrils derived from a particular antibody light chain. Cardiac involvement is a major risk factor for mortality. Using MAS solid-state NMR, we studied the fibril structure of a recombinant light chain fragment...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Pradhan, Tejaswini, Annamalai, Karthikeyan, Sarkar, Riddhiman, Huhn, Stefanie, Hegenbart, Ute, Schönland, Stefan, Fändrich, Marcus, Reif, Bernd
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2021
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939468/
https://ncbi.nlm.nih.gov/pubmed/33093170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016006
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