Critical Role of Flanking Residues in NGR-to-isoDGR Transition and CD13/Integrin Receptor Switching

Various NGR-containing peptides have been exploited for targeted delivery of drugs to CD13-positive tumor neovasculature. Recent studies have shown that compounds containing this motif can rapidly deamidate and generate isoaspartate-glycine-arginine (isoDGR), a ligand of αvβ3-integrin that can be al...

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Hlavní autoři: Curnis, Flavio, Cattaneo, Angela, Longhi, Renato, Sacchi, Angelina, Gasparri, Anna Maria, Pastorino, Fabio, Di Matteo, Paola, Traversari, Catia, Bachi, Angela, Ponzoni, Mirco, Rizzardi, Gian-Paolo, Corti, Angelo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838331/
https://ncbi.nlm.nih.gov/pubmed/20064928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.044297
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