A Residue-specific Shift in Stability and Amyloidogenicity of Antibody Variable Domains

Variable (V) domains of antibodies are essential for antigen recognition by our adaptive immune system. However, some variants of the light chain V domains (V(L)) form pathogenic amyloid fibrils in patients. It is so far unclear which residues play a key role in governing these processes. Here, we s...

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Detalhes bibliográficos
Main Authors: Nokwe, Cardine N., Zacharias, Martin, Yagi, Hisashi, Hora, Manuel, Reif, Bernd, Goto, Yuji, Buchner, Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4175325/
https://ncbi.nlm.nih.gov/pubmed/25096580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.582247
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