A single residue switch reveals principles of antibody domain integrity

Despite their importance for antibody architecture and design, the principles governing antibody domain stability are still not understood in sufficient detail. Here, to address this question, we chose a domain from the invariant part of IgG, the C(H)2 domain. We found that compared with other Ig do...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Weber, Benedikt, Brandl, Matthias J., Pulido Cendales, María Daniela, Berner, Carolin, Pradhan, Tejaswini, Feind, Gina Maria, Zacharias, Martin, Reif, Bernd, Buchner, Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222096/
https://ncbi.nlm.nih.gov/pubmed/30228183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005475
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