Fatal amyloid formation in a patient’s antibody light chain is caused by a single point mutation

In systemic light chain amyloidosis, an overexpressed antibody light chain (LC) forms fibrils which deposit in organs and cause their failure. While it is well-established that mutations in the LC’s V(L) domain are important prerequisites, the mechanisms which render a patient LC amyloidogenic are i...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Kazman, Pamina, Vielberg, Marie-Theres, Pulido Cendales, María Daniela, Hunziger, Lioba, Weber, Benedikt, Hegenbart, Ute, Zacharias, Martin, Köhler, Rolf, Schönland, Stefan, Groll, Michael, Buchner, Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064341/
https://ncbi.nlm.nih.gov/pubmed/32151314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52300
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