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Molecular mechanism of amyloidogenic mutations in hypervariable regions of antibody light chains
Systemic light chain (AL) amyloidosis is a fatal protein misfolding disease in which excessive secretion, misfolding, and subsequent aggregation of free antibody light chains eventually lead to deposition of amyloid plaques in various organs. Patient-specific mutations in the antibody V(L) domain ar...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7949129/ https://ncbi.nlm.nih.gov/pubmed/33508322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100334 |
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