Molecular mechanism of amyloidogenic mutations in hypervariable regions of antibody light chains

Systemic light chain (AL) amyloidosis is a fatal protein misfolding disease in which excessive secretion, misfolding, and subsequent aggregation of free antibody light chains eventually lead to deposition of amyloid plaques in various organs. Patient-specific mutations in the antibody V(L) domain ar...

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Publicat a:J Biol Chem
Autors principals: Rottenaicher, Georg J., Weber, Benedikt, Rührnößl, Florian, Kazman, Pamina, Absmeier, Ramona M., Hitzenberger, Manuel, Zacharias, Martin, Buchner, Johannes
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7949129/
https://ncbi.nlm.nih.gov/pubmed/33508322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100334
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