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Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains
Antibody light chain amyloidosis is a rare disease caused by fibril formation of secreted immunoglobulin light chains (LCs). The huge variety of antibody sequences puts a serious challenge to drug discovery. The green tea polyphenol epigallocatechin-3-gallate (EGCG) is known to interfere with fibril...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5269747/ https://ncbi.nlm.nih.gov/pubmed/28128355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41515 |
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