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MAK33 antibody light chain amyloid fibrils are similar to oligomeric precursors

Little structural information is available so far on amyloid fibrils consisting of immunoglobulin light chains. It is not understood which features of the primary sequence of the protein result in fibril formation. We report here MAS solid-state NMR studies to identify the structured core of κ-type...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Hora, Manuel, Sarkar, Riddhiman, Morris, Vanessa, Xue, Kai, Prade, Elke, Harding, Emma, Buchner, Johannes, Reif, Bernd
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528828/
https://ncbi.nlm.nih.gov/pubmed/28746363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181799
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