MAK33 antibody light chain amyloid fibrils are similar to oligomeric precursors

Little structural information is available so far on amyloid fibrils consisting of immunoglobulin light chains. It is not understood which features of the primary sequence of the protein result in fibril formation. We report here MAS solid-state NMR studies to identify the structured core of κ-type...

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Bibliographic Details
Published in:PLoS One
Main Authors: Hora, Manuel, Sarkar, Riddhiman, Morris, Vanessa, Xue, Kai, Prade, Elke, Harding, Emma, Buchner, Johannes, Reif, Bernd
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528828/
https://ncbi.nlm.nih.gov/pubmed/28746363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181799
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