Genotoxicity of tetrahydrofolic acid to hematopoietic stem and progenitor cells

Metabolically reactive formaldehyde is a genotoxin and a carcinogen. Mice lacking the main formaldehyde-detoxifying gene Adh5 combined with the loss of the Fanconi anemia (FA) DNA repair pathway rapidly succumbed to bone marrow failure (BMF) primarily due to the extensive ablation of the hematopoiet...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Differ
Egile Nagusiak: García-Calderón, Clara B., Bejarano-García, José Antonio, Tinoco-Gago, Isabel, Castro, María José, Moreno-Gordillo, Paula, Piruat, José I., Caballero-Velázquez, Teresa, Pérez-Simón, José A., Rosado, Iván V.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219486/
https://ncbi.nlm.nih.gov/pubmed/29511342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0089-4
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