Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion

It is established that hematopoietic stem cells (HSC) in the hypoxic bone marrow have adapted their metabolism to oxygen-limiting conditions. This adaptation includes suppression of mitochondrial activity, induction of anerobic glycolysis, and activation of hypoxia-inducible transcription factor 1α...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Bejarano-García, José Antonio, Millán-Uclés, África, Rosado, Iván V, Sánchez-Abarca, Luís Ignacio, Caballero-Velázquez, Teresa, Durán-Galván, María José, Pérez-Simón, José Antonio, Piruat, José I
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5261010/
https://ncbi.nlm.nih.gov/pubmed/27929539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.411
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