Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion

It is established that hematopoietic stem cells (HSC) in the hypoxic bone marrow have adapted their metabolism to oxygen-limiting conditions. This adaptation includes suppression of mitochondrial activity, induction of anerobic glycolysis, and activation of hypoxia-inducible transcription factor 1α...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell Death Dis
Päätekijät: Bejarano-García, José Antonio, Millán-Uclés, África, Rosado, Iván V, Sánchez-Abarca, Luís Ignacio, Caballero-Velázquez, Teresa, Durán-Galván, María José, Pérez-Simón, José Antonio, Piruat, José I
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2016
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5261010/
https://ncbi.nlm.nih.gov/pubmed/27929539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.411
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